hrp0094fc6.5 | Bone and Mineral Metabolism | ESPE2021

What is the natural history of cervicomedullary compression without signal change in infants with achondroplasia? Investigating foramen magnum stenosis evolution.

Harvey Charlotte , Brett Connor , Cocca Alessandra , D’Arco Felice , Irving Melita , Thompson Dominic , Cheung Moira ,

Background: Foramen magnum stenosis (FMS) is a common, serious complication of achondroplasia in infancy. The Achondroplasia Foramen Magnum Score (AFMS; 1-4) was developed to facilitate early detection of stenosis and inform appropriate neurosurgical management. All infants have a baseline screening MRI, of which approximately half of cases demonstrate AFMS3 (craniovertebral junction (CVJ) narrowing with flattening of the cervical cord) or AFMS4 (CVJ narrowing...